Propranolol kinetics in plasma from severely burned adults.

ABSTRACT:

Objectives

The aim of this study was to determine the appropriate propranolol dosing strategy for reducing heart rate in severely burned adults.

Methods

A total of 26 patients (≥18 years) with burns covering ≥30% of the total body surface area were included in this IRB-approved study. Plasma propranolol concentrations were determined in a placebo group (n=10) or following one of three dosing strategies: Q6 (n=4), Q8 (n=6), and Q24 (n=6). Blood was collected just before dosing and at regular intervals over two dosing periods with corresponding heart rate and blood pressure recordings. Statistical significance was determined by one-way ANOVA followed by the appropriate post-hoc test.

Results

Heart rate was 86±2 bpm for Q6, 93±3 bpm for Q8, and 90±4 bpm for Q24. The Q8 g

SUBMITTER: Guillory AN 

PROVIDER: S-EPMC8173765 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature