Intensity of Renal Replacement Therapy and Duration of Mechanical Ventilation: Secondary Analysis of the Acute Renal Failure Trial Network Study.

ABSTRACT:

Background

Randomized clinical trials have failed to show benefit from increasing intensity of renal replacement therapy (RRT) for acute kidney injury, but continue to be frequently used. In addition, intensive RRT is associated with an increase in adverse events potentially secondary to small solute losses, such as phosphate. We hypothesized that, compared with less-intensive RRT, intensive RRT would lead to longer duration of mechanical ventilation.

Research question

Does more-intensive renal replacement therapy in critically ill patients with acute kidney injury increase time to extubation from mechanical ventilation when compared with less-intensive therapy?

Study design and methods

The Acute Renal Failure Trial Network study was a randomized multicenter trial of

SUBMITTER: Sharma S 

PROVIDER: S-EPMC8173776 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature