Dysbiosis of the gut microbiome is a risk factor for osteoarthritis in older female adults: a case control study.

ABSTRACT:

Background

Osteoarthritis (OA) is a multifactorial joint degenerative disease with low-grade inflammation. The gut microbiome has recently emerged as an pathogenic factor of OA, and prebiotics supplementation could alleviate OA symptoms in animal models. However, the relationship between the gut microbiome and OA in the older female adults is hitherto not clear.

Results

Here we studied the gut microbiome of 57 OA patients and their healthy controls by metagenome-wide association study based on previously published data. A significant reduction in the richness and diversity of gut microbiome were observed in OA patients. Bifidobacterium longum and Faecalibacterium prausnitzii were decreased while Clostridium spp. was increased in the OA group. The functional modules, particul

SUBMITTER: Chen J 

PROVIDER: S-EPMC8173911 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature