Naive CD4⁺ cell counts significantly decay and high HIV RNA levels contribute to immunological progression in long-term non-progressors infected with HIV by blood products: a cohort study.

ABSTRACT:

Background

Some long-term non-progressors (LTNPs) have decreasing CD4⁺ T cell counts and progress to AIDS. Exploring which subsets of CD4⁺ T cell decreasing and the determinants associated with the decay in these patients will improve disease progression surveillance and provide further understanding of HIV pathogenesis.

Methods

Twenty-five LTNPs infected with HIV by blood products were classified as decreased (DG) if their CD4⁺ cell count dropped to < 400 cells/μL during follow-up or as non-decreased (non-DG) if their CD4⁺ cell count was ≥400 cells/μL. Laboratory and clinical assessments were conducted at 6 consecutive visits to identify DG characteristics.

Results

The LTNPs were infected with HIV for 12 (IQR: 11.5-14) year

SUBMITTER: Xu L 

PROVIDER: S-EPMC8173962 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature