Reduced fecal short-chain fatty acids levels and the relationship with gut microbiota in IgA nephropathy.

ABSTRACT:

Background

IgA nephropathy(IgAN)) is the common pathological type of glomerular diseases. The role of gut microbiota in mediating "gut-IgA nephropathy" has not received sufficient attention in the previous studies. The purpose of this study was to investigate the changes of fecal short-chain fatty acids(SCFAs), a metabolite of the intestinal microbiota, in patients with IgAN and its correlation with intestinal flora and clinical indicators, and to further investigate the role of the gut-renal axis in IgAN.

Methods

There were 29 patients with IgAN and 29 normal control subjects recruited from January 2018 to May 2018. The fresh feces were collected. The fecal SCFAs were measured by gas chromatography/mass spectrometry and gut microbiota was analysed by16S rDNA sequences, foll

SUBMITTER: Chai L 

PROVIDER: S-EPMC8173972 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature