Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model.

ABSTRACT:

Purpose

Diffusion-weighted MRI (DW-MRI) is a contrast-free modality that has demonstrated ability to discriminate between predefined benign and malignant breast lesions. However, how well DW-MRI discriminates cancer from all other breast tissue voxels in a clinical setting is unknown. Here we explore the voxelwise ability to distinguish cancer from healthy breast tissue using signal contributions from the newly developed three-component multi-b-value DW-MRI model.

Experimental design

Patients with pathology-proven breast cancer from two datasets (n = 81 and n = 25) underwent multi-b-value DW-MRI. The three-component signal contributions C ₁ and C ₂ and their product, C ₁ C ₂, and signal fra

SUBMITTER: Andreassen MMS 

PROVIDER: S-EPMC8174004 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature