Different Effects of Alcohol Exposure on Action and Outcome-Related Orbitofrontal Cortex Activity.

ABSTRACT: Alcohol dependence can result in long-lasting deficits to decision-making and action control. Neurobiological investigations have identified orbitofrontal cortex (OFC) as important for outcome-related contributions to goal-directed actions during decision-making. Prior work has shown that alcohol dependence induces long-lasting changes to OFC function that persist into protracted withdrawal and disrupts goal-directed control over actions. However, it is unclear whether these changes in function alter representation of action and outcome-related neural activity in OFC. Here, we used the well-validated chronic intermittent ethanol (CIE) exposure and withdrawal procedure to model alcohol dependence in mice and performed in vivo extracellular recordings during an instrumental task in wh

SUBMITTER: Cazares C 

PROVIDER: S-EPMC8174034 | biostudies-literature | 2021 Mar-Apr

REPOSITORIES: biostudies-literature