[miR-144-3p Inhibits the Invasion and Metastasis of Lung Adenocarcinoma Cells 
by Targeting IRS1].

ABSTRACT:

Background

MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression, influence cellular processes, and promote disease development. Variations in miRNA expression have been observed in many diseases, including hepatitis, cardiovascular disease, and cancer. The aim of this study is to investigate the effect of miR-144-3p on the invasion and metastasis of lung adenocarcinoma by targeting recombinant insulin receptor substrate 1 (IRS1).

Methods

The expression of miR-144-3p in patients with lung adenocarcinoma was queried through bioinformatics database. MirTarPathway was used to analyze the KEGG enrichment pathway of miRNA. The expression and plasmid transfection efficiency of miR-144-3p in lung adenocarcinoma cell lines were detected by quantitative reverse t

SUBMITTER: Bai J 

PROVIDER: S-EPMC8174106 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature