What is required for achieving hepatitis C virus elimination in Singapore? A modeling study.

ABSTRACT:

Background and aim

The vast majority of hepatitis C virus (HCV) infection in Singapore is among those with a history of injecting drug use (IDU), yet harm reduction is not available and what is required to achieve the World Health Organization (WHO) HCV elimination targets (80% incidence reduction and 65% mortality reduction by 2030) is unknown. We model the intervention scale-up required to achieve WHO targets in Singapore.

Methods

A dynamic model of HCV transmission and progression among those with a history of IDU was calibrated to Singapore, a setting with declining IDU and no harm reduction (~11 000 people with IDU history in 2017 and 45% HCV seropositive). We projected HCV treatment scale-up from 2019 required to achieve WHO targets with varying prioritization scenario

SUBMITTER: Chaillon A 

PROVIDER: S-EPMC8174139 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature