Antenatal Hypoxia Affects Pulmonary Artery Contractile Functions via Downregulating L-type Ca²⁺ Channels Subunit Alpha1 C in Adult Male Offspring.

ABSTRACT: Background Antenatal intrauterine fetal hypoxia is a common pregnancy complication that has profound adverse effects on an individual's vascular health later in life. Pulmonary arteries are sensitive to hypoxia, but adverse effects of antenatal hypoxia on pulmonary vasoreactivities in the offspring remain unknown. This study aimed to determine the effects and related mechanisms of antenatal hypoxia on pulmonary artery functions in adult male offspring. Methods and Results Pregnant Sprague-Dawley rats were housed in a normoxic or hypoxic (10.5% O₂) chamber from gestation days 10 to 20. Male offspring were euthanized at 16 weeks old (adult offspring). Pulmonary arteries were collected for vascular function, electrophysiology, target gene expression, and promoter methylation studie

SUBMITTER: Li H 

PROVIDER: S-EPMC8174167 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature