Recombinant Soluble Corin Improves Cardiac Function in Mouse Models of Heart Failure.

ABSTRACT: Background Corin is a transmembrane protease that activates ANP and BNP (atrial and B-type natriuretic peptides). Impaired corin expression and function are associated with heart failure. In this study, we characterized a soluble form of corin (sCorin) and examined its effects on cardiac morphology and function in mouse heart failure models. Methods and Results sCorin, consisting of the full-length extracellular fragment of human corin with an engineered activation site, was expressed in Chinese hamster ovary cells, purified from the conditioned medium with affinity chromatography, and characterized in pro-ANP processing assays in vitro and pharmacokinetic studies in mice. Effects of sCorin on mouse models of heart failure induced by left coronary artery ligation and transverse aortic cons

SUBMITTER: Niu Y 

PROVIDER: S-EPMC8174325 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature