Association of Small Intestinal Bacterial Overgrowth With Heart Failure and Its Prediction for Short-Term Outcomes.

ABSTRACT: Background Small intestinal bacterial overgrowth (SIBO) is a common pathological condition of intestinal microbiota. The prevalence of SIBO and its prognostic value in patients with heart failure (HF) are unknown. Methods and Results A total of 287 patients tested for SIBO using lactulose hydrogen-methane breath test were evaluated. At least 1 of the following criteria fulfilled was SIBO positive: patients with fasting hydrogen level ≥20 parts per million (ppm) or a ≥20 ppm rise in hydrogen by 90 minutes were diagnosed with SIBO (H₂) positive; and patients with methane levels ≥10 ppm at any test point were diagnosed with SIBO (CH₄) positive. The association between SIBO and the composite of cardiovascular death and HF rehospitalization was investigated. In 287 consecu

SUBMITTER: Song Y 

PROVIDER: S-EPMC8174348 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature