Consensus Transcriptional Landscape of Human End-Stage Heart Failure.

ABSTRACT: Background Transcriptomic studies have contributed to fundamental knowledge of myocardial remodeling in human heart failure (HF). However, the key HF genes reported are often inconsistent between studies, and systematic efforts to integrate evidence from multiple patient cohorts are lacking. Here, we aimed to provide a framework for comprehensive comparison and analysis of publicly available data sets resulting in an unbiased consensus transcriptional signature of human end-stage HF. Methods and Results We curated and uniformly processed 16 public transcriptomic studies of left ventricular samples from 263 healthy and 653 failing human hearts. First, we evaluated the degree of consistency between studies by using linear classifiers and overrepresentation analysis. Then, we meta-analyzed th

SUBMITTER: Ramirez Flores RO 

PROVIDER: S-EPMC8174362 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature