Testosterone Metabolite 6β-Hydroxytestosterone Contributes to Angiotensin II-Induced Abdominal Aortic Aneurysms in Apoe^-/- Male Mice.

ABSTRACT: Background Sex is a prominent risk factor for abdominal aortic aneurysms (AAAs), and angiotensin II (Ang II) induces AAA formation to a greater degree in male than in female mice. We previously reported that cytochrome P450 1B1 contributes to the development of hypertension, as well as AAAs, in male mice. We also found that a cytochrome P450 1B1-generated metabolite of testosterone, 6β-hydroxytestosterone (6β-OHT), contributes to Ang II-induced hypertension and associated cardiovascular and renal pathogenesis in male mice. The current study was conducted to determine the contribution of 6β-OHT to Ang II-induced AAA development in Apoe^-/- male mice. Methods and Results Intact or castrated Apoe^-/-/Cyp1b1^+/+ and Apoe^-/-/Cyp1b1^-

SUBMITTER: Mukherjee K 

PROVIDER: S-EPMC8174379 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature