Rapid development of vasopressin resistance in dietary K⁺ deficiency.

ABSTRACT: The association between diabetes insipidus (DI) and chronic dietary K⁺ deprivation is well known, but it remains uncertain how the disorder develops and whether it is influenced by the sexual dimorphism in K⁺ handling. Here, we determined the plasma K⁺ (P_K) threshold for DI in male and female mice and ascertained if DI is initiated by polydipsia or by a central or nephrogenic defect. C57BL6J mice were randomized to a control diet or to graded reductions in dietary K⁺ for 8 days, and kidney function and transporters involved in water balance were characterized. We found that male and female mice develop polyuria and secondary polydipsia. Altered water balance coincided with a decrease in aquaporin-2 (AQP2) phosphorylation and apical loc

SUBMITTER: Al-Qusairi L 

PROVIDER: S-EPMC8174811 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature