The Genetic Variation of Lactase Persistence Alleles in Sudan and South Sudan.

ABSTRACT: Lactase persistence (LP) is a well-studied example of a Mendelian trait under selection in some human groups due to gene-culture coevolution. We investigated the frequencies of genetic variants linked to LP in Sudanese and South Sudanese populations. These populations have diverse subsistence patterns, and some are dependent on milk to various extents, not only from cows but also from other livestock such as camels and goats. We sequenced a 316-bp region involved in regulating the expression of the LCT gene on chromosome 2, which encompasses five polymorphisms that have been associated with LP. Pastoralist populations showed a higher frequency of LP-associated alleles compared with nonpastoralist groups, hinting at positive selection also among northeast African pastoralists. Among the LP

SUBMITTER: Hollfelder N 

PROVIDER: S-EPMC8175049 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature