Ontology highlight
ABSTRACT:
SUBMITTER: Kern N
PROVIDER: S-EPMC8175083 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Kern Nadja N Dong Rui R Douglas Shawn M SM Vale Ronald D RD Morrissey Meghan A MA
eLife 20210603
Macrophages destroy pathogens and diseased cells through Fcγ receptor (FcγR)-driven phagocytosis of antibody-opsonized targets. Phagocytosis requires activation of multiple FcγRs, but the mechanism controlling the threshold for response is unclear. We developed a DNA origami-based engulfment system that allows precise nanoscale control of the number and spacing of ligands. When the number of ligands remains constant, reducing ligand spacing from 17.5 nm to 7 nm potently enhances engulfment, prim ...[more]