Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges.

ABSTRACT: In spite of the considerable achievements in the field of regenerative medicine in the past several decades, osteochondral defect regeneration remains a challenging issue among diseases in the musculoskeletal system because of the spatial complexity of osteochondral units in composition, structure and functions. In order to repair the hierarchical tissue involving different layers of articular cartilage, cartilage-bone interface and subchondral bone, traditional clinical treatments including palliative and reparative methods have showed certain improvement in pain relief and defect filling. It is the development of tissue engineering that has provided more promising results in regenerating neo-tissues with comparable compositional, structural and functional characteristics to the native os

SUBMITTER: Wei W 

PROVIDER: S-EPMC8175243 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature