Outcomes of clinical utility in amyloid-PET studies: state of art and future perspectives.

ABSTRACT:

Purpose

To review how outcomes of clinical utility are operationalized in current amyloid-PET validation studies, to prepare for formal assessment of clinical utility of amyloid-PET-based diagnosis.

Methods

Systematic review of amyloid-PET research studies published up to April 2020 that included outcomes of clinical utility. We extracted and analyzed (a) outcome categories, (b) their definition, and (c) their methods of assessment.

Results

Thirty-two studies were eligible. (a) Outcome categories were clinician-centered (found in 25/32 studies, 78%), patient-/caregiver-centered (in 9/32 studies, 28%), and health economics-centered (5/32, 16%). (b) Definition: Outcomes were mainly defined by clinical researchers; only the ABIDE study expressly included stakeholders in

SUBMITTER: Cotta Ramusino M 

PROVIDER: S-EPMC8175294 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature