A multisite analysis of the concordance between visual image interpretation and quantitative analysis of [¹⁸F]flutemetamol amyloid PET images.

ABSTRACT:

Background

[¹⁸F]flutemetamol PET scanning provides information on brain amyloid load and has been approved for routine clinical use based upon visual interpretation as either negative (equating to none or sparse amyloid plaques) or amyloid positive (equating to moderate or frequent plaques). Quantitation is however fundamental to the practice of nuclear medicine and hence can be used to supplement amyloid reading methodology especially in unclear cases.

Methods

A total of 2770 [¹⁸F]flutemetamol images were collected from 3 clinical studies and 6 research cohorts with available visual reading of [¹⁸F]flutemetamol and quantitative analysis of images. These were assessed further to examine both the discordance and concordance between visual and

SUBMITTER: Bucci M 

PROVIDER: S-EPMC8175298 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature