Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia.

ABSTRACT:

Purpose

To examine associations between the APOE-ε2 and APOE-ε4 alleles and core Alzheimer's disease (AD) pathological hallmarks as measured by amyloid-β (Aβ) and tau PET in older individuals without dementia.

Methods

We analyzed data from 462 ADNI participants without dementia who underwent Aβ ([¹⁸F]florbetapir or [¹⁸F]florbetaben) and tau ([¹⁸F]flortaucipir) PET, structural MRI, and cognitive testing. Employing APOE-ε3 homozygotes as the reference group, associations between APOE-ε2 and APOE-ε4 carriership with global Aβ PET and regional tau PET measures (entorhinal cortex (ERC), inferior temporal cortex, and Braak-V/VI neocortical composite regions) were investigated using linear regression models. In a subset of 156 participants, we also

SUBMITTER: Salvado G 

PROVIDER: S-EPMC8175302 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature