Diagnostic value of amyloid-PET and tau-PET: a head-to-head comparison.

ABSTRACT:

Purpose

Assess the individual and combined diagnostic value of amyloid-PET and tau-PET in a memory clinic population.

Methods

Clinical reports of 136 patients were randomly assigned to two diagnostic pathways: AMY-TAU, amyloid-PET is presented before tau-PET; and TAU-AMY, tau-PET is presented before amyloid-PET. Two neurologists independently assessed all reports with a balanced randomized design, and expressed etiological diagnosis and diagnostic confidence (50-100%) three times: (i) at baseline based on the routine diagnostic workup, (ii) after the first exam (amyloid-PET for the AMY-TAU pathway, and tau-PET for the TAU-AMY pathway), and (iii) after the remaining exam. The main outcomes were changes in diagnosis (from AD to non-AD or vice versa) and in diagnostic confidenc

SUBMITTER: Altomare D 

PROVIDER: S-EPMC8175315 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature