Hemodynamic and biological correlates of glomerular hyperfiltration in sickle cell patients before and under renin-angiotensin system blocker.

ABSTRACT: Glomerular hyperfiltration alone or associated with albuminuria is a well-known feature of sickle cell associated nephropathy. Though, glomerular hyperfiltration is currently considered to be related to a high renal plasma flow and chronic hemolysis, cardiac output influence on measured glomerular filtration rate (mGFR) have not been investigated so far. Thirty seven homozygous sickle cell patients (SCA) from the RAND study investigated before and under angiotensin converting enzyme inhibitor (ACEI) were included. Both mGFR and cardiac index (CI) were high (> 110 ml/min/1.73 m² and > 3.5 l/m² in 81% and 97% of cases) with low systemic vascular resistance (SVR) (< 700 dynes/s/cm^-5) in 38% of cases. mGFR association with CI and SVR were significant at baselin

SUBMITTER: Haymann JP 

PROVIDER: S-EPMC8175337 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature