Long-term stability of computational parameters during approach-avoidance conflict in a transdiagnostic psychiatric patient sample.

ABSTRACT: Maladaptive behavior during approach-avoidance conflict (AAC) is common to multiple psychiatric disorders. Using computational modeling, we previously reported that individuals with depression, anxiety, and substance use disorders (DEP/ANX; SUDs) exhibited differences in decision uncertainty and sensitivity to negative outcomes versus reward (emotional conflict) relative to healthy controls (HCs). However, it remains unknown whether these computational parameters and group differences are stable over time. We analyzed 1-year follow-up data from a subset of the same participants (N = 325) to assess parameter stability and relationships to other clinical and task measures. We assessed group differences in the entire sample as well as a subset matched for age and IQ across HCs (N = 48), SUDs

SUBMITTER: Smith R 

PROVIDER: S-EPMC8175390 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature