Loss of FOXO transcription factors in the liver mitigates stress-induced hyperglycemia.

ABSTRACT:

Objective

Stress-induced hyperglycemia is associated with poor outcomes in nearly all critical illnesses. This acute elevation in glucose after injury or illness is associated with increased morbidity and mortality, including multiple organ failure. Stress-induced hyperglycemia is often attributed to insulin resistance as controlling glucose levels via exogenous insulin improves outcomes, but the mechanisms are unclear. Forkhead box O (FOXO) transcription factors are direct targets of insulin signaling in the liver that regulate glucose homeostasis via direct and indirect pathways. Loss of hepatic FOXO transcription factors reduces hyperglycemia in chronic insulin resistance; however, the role of FOXOs in stress-induced hyperglycemia is unknown.

Methods

We subjected mice lac

SUBMITTER: Garcia Whitlock AE 

PROVIDER: S-EPMC8175408 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature