Genome-wide association study on blood pressure traits in the Iranian population suggests ZBED9 as a new locus for hypertension.

ABSTRACT: High blood pressure is the heritable risk factor for cardiovascular and kidney diseases. Genome-wide association studies(GWAS) on blood pressure traits increase our understanding of its underlying genetic basis. However, a large proportion of GWAS was conducted in Europeans, and some roadblocks deprive other populations to benefit from their results. Iranians population with a high degree of genomic specificity has not been represented in international databases to date, so to fill the gap, we explored the effects of 652,919 genomic variants on Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), and Hypertension (HTN) in 7694 Iranian adults aged 18 and over from Tehran Cardiometabolic Genetic Study (TCGS). We identified consistent signals on ZBED9 associated with HTN in the geno

SUBMITTER: Kolifarhood G 

PROVIDER: S-EPMC8175429 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature