A Cohort Study of Anticholinergic Medication Burden and Incident Dementia and Stroke in Older Adults.

ABSTRACT:

Background

Anticholinergic medications may increase risk of dementia and stroke, but prospective studies in healthy older people are lacking.

Objective

Compare risk of incident dementia and stroke by anticholinergic burden among initially healthy older people.

Design

Prospective cohort study.

Setting

Primary care (Australia and USA).

Participants

19,114 community-dwelling participants recruited for the ASPREE trial, aged 70+ years (65+ if US minorities) without major cardiovascular disease, dementia diagnosis, or Modified Mini-Mental State Examination score below 78/100.

Measurements

Baseline anticholinergic exposure was calculated using the Anticholinergic Cognitive Burden (ACB) score. Dementia was adjudicated using Diagnostic and Statistical Man

SUBMITTER: Lockery JE 

PROVIDER: S-EPMC8175463 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature