Effects of Alzheimer's Disease-Related Proteins on the Chirality of Brain Endothelial Cells.

ABSTRACT:

Introduction

Cell chirality is an intrinsic cellular property that determines the directionality of cellular polarization along the left-right axis. We recently show that endothelial cell chirality can influence intercellular junction formation and alter trans-endothelial permeability, depending on the uniformity of the chirality of adjacent cells, which suggests a potential role for cell chirality in neurodegenerative diseases with blood-brain barrier (BBB) dysfunctions, such as Alzheimer's disease (AD). In this study, we determined the effects of AD-related proteins amyloid-β (Aβ), tau, and apolipoprotein E4 (ApoE4) on the chiral bias of the endothelial cell component in BBB.

Methods

We first examined the chiral bias and effects of protein kinase C (PKC)-mediated chiral al

SUBMITTER: Zhang H 

PROVIDER: S-EPMC8175509 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature