Ontology highlight
ABSTRACT:
SUBMITTER: Soboleva S
PROVIDER: S-EPMC8175573 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Soboleva Svetlana S Kurita Ryo R Ek Fredrik F Åkerstrand Hugo H Silvério-Alves Rita R Olsson Roger R Nakamura Yukio Y Miharada Kenichi K
Communications biology 20210603 1
Immortalized erythroid cell lines are expected to be a promising source of ex vivo manufactured red blood cells (RBCs), however the induction of enucleation in these cell lines is inefficient at present. We utilized an imaging-based high-throughput system to identify chemical compounds that trigger enucleation of human erythroid cell lines. Among >3,300 compounds, we identified multiple histone deacetylase inhibitors (HDACi) inducing enucleated cells from the cell line, although an increase in m ...[more]