Transformation of SOX9⁺ cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma.

ABSTRACT: SOX9 (Sex-determining region Y Box 9) is a well-characterized transcription factor that is a marker for progenitor cells in various tissues. In the liver, cells delineated by SOX9 are responsible for regenerating liver parenchyma when cell proliferation is impaired following chronic injury. However, whether these SOX9⁺ cells play a role in liver carcinogenesis has not been fully understood, although high SOX9 expression has been linked to poor survival outcome in liver cancer patients. To address this question, we developed a liver cancer mouse model (Pten^loxP/loxP; Sox9-Cre^ERT+; R26R^YFP) where tumor suppressor Pten (phosphatase and tensin homolog deleted on chromosome ten) is deleted in SOX9⁺ cells following tamoxifen injection. In th

SUBMITTER: Chen J 

PROVIDER: S-EPMC8175600 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature