Dataset Information

Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study.

ABSTRACT: Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case-control study (2008-2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multivariable adjusted logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (CI) for cancer, across categories of sleep duration (≤ 5, 6, 7, 8, ≥ 9 hours/day), daytime napping frequency (naps/week) and duration (minutes/nap). Compared to 7 hours of sleep, long sleep was associated with increased odds of colorectal (OR_≥9 hours: 1.59; 95%CI 1.30-1.94) and gastric cancer (OR_≥9 hours: 1.95; 1.37-2.76); short sleep was associated with increased odds of gastric cancer (OR_≤5 hours: 1.32; 0.93-1.88). Frequent and long daytime naps increased the odds of colorectal (OR_{6-7 naps/week, ≥30 min}: 1.32; 1.14-1.54) and gastric cancer (OR_{6-7 naps/week, ≥30 min}: 1.56; 1.21-2.02). Effects of short sleep and frequent long naps were stronger among participants with night shift-work history. Sleep and circadian disruption may jointly play a role in the etiology of colorectal and gastric cancer.

SUBMITTER: Papantoniou K

PROVIDER: S-EPMC8175745 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study.

Papantoniou Kyriaki K Castaño-Vinyals Gemma G Espinosa Ana A Turner Michelle C MC Martín-Sánchez Vicente V Casabonne Delphine D Aragonés Nuria N Gómez-Acebo Inés I Ardanaz Eva E Jimenez-Moleon Jose-Juan JJ Amiano Pilar P Molina-Barceló Ana A Alguacil Juan J Fernández-Tardón Guillermo G Huerta José María JM Hernández-Segura Natalia N Perez-Gomez Beatriz B Llorca Javier J Vidán-Alli Juana J Olmedo-Requena Rocıo R Gil Leire L Castañon-López Carmen C Pollan Marina M Kogevinas Manolis M Moreno Victor V

Scientific reports 20210603 1

Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case-control study (2008-2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multi ...[more]

PMID: 34083698

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Project description:BackgroundChronic inadequate sleep and frequent daytime napping may inflict deleterious health effects including weight gain, cardiometabolic and psychiatric diseases, and cancer. It is plausible that these relations may be partly influenced by the consumption of suboptimal diets.ObjectivesThe study aimed to identify potential causal links of genetically proxied longer habitual sleep duration and more frequent daytime napping on 61 dietary variables derived from an FFQ. In addition, the study aimed to assess potential bidirectional causal links between habitual sleep duration or daytime napping and macronutrient composition.MethodsGenetic variants robustly associated with habitual sleep duration and daytime napping from published genome-wide association analyses were used. Outcomes included 61 dietary variables estimated from FFQs in the UK Biobank (n = 361,194). For bidirectional associations with macronutrient composition, genetic variants associated with percentage of energy from carbohydrate, fat, and protein were used. Two-sample Mendelian randomization (MR) effects were estimated with inverse-variance weighted (IVW) analysis.ResultsIn 2-sample MR, genetically proxied longer sleep duration was associated with a 0.068 (95% CI: 0.034, 0.103) category increase in salad/raw vegetable intake [P false discovery rate (FDR) = 0.006] per hour of sleep and with "no major dietary changes in the past 5 years" (P FDR = 0.043). No associations were evident for daytime napping on dietary variables (all P FDR > 0.05). In addition, there were no bidirectional associations between habitual sleep duration or daytime napping with the relative intake of carbohydrate, fat, and protein (all P IVW > 0.05).ConclusionsIn this MR study, there was modest evidence for associations between habitual sleep duration with dietary intake and no evidence for associations between daytime napping frequency with dietary intake. These preliminary findings suggest that changes to habitual sleep duration or daytime napping frequency may have limited impact on long-term changes in dietary intake.

Dataset Information

Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study.

Publications

Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study.

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