Genistein From Fructus sophorae Protects Mice From Radiation-Induced Intestinal Injury.

ABSTRACT: The development of an effective pharmacological countermeasure is needed to reduce the morbidity and mortality in high-dose ionizing radiation-induced acute damage. Genistein has shown bioactivity in alleviating radiation damage and is currently synthesized by chemosynthetic methods. Due to concerns about chemical residues and high costs, the clinical application of genistein is still a major challenge. In this study, we aimed to establish an efficient method for the extraction of genistein from Fructus sophorae. The effects of extracted genistein (FSGen) on preventing intestinal injury from radiation were further investigated in this study. C57/BL mice were exposed to 7.5 Gy whole body irradiation with and without FSGen treatments. Histological analysis demonstrated significant str

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8175795 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature