Plasma Membrane Calcium ATPase Regulates Stoichiometry of CD4⁺ T-Cell Compartments.

ABSTRACT: Immune responses involve mobilization of T cells within naïve and memory compartments. Tightly regulated Ca²⁺ levels are essential for balanced immune outcomes. How Ca²⁺ contributes to regulating compartment stoichiometry is unknown. Here, we show that plasma membrane Ca²⁺ ATPase 4 (PMCA4) is differentially expressed in human CD4⁺ T compartments yielding distinct store operated Ca²⁺ entry (SOCE) profiles. Modulation of PMCA4 yielded a more prominent increase of SOCE in memory than in naïve CD4⁺ T cell. Interestingly, downregulation of PMCA4 reduced the effector compartment fraction and led to accumulation of cells in the naïve compartment. In silico analysis and chromatin immunoprecipitation point towards Ying Yang 1

SUBMITTER: Merino-Wong M 

PROVIDER: S-EPMC8175910 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature