Accurate Prediction of Prognosis by Integrating Clinical and Molecular Characteristics in Colon Cancer.

ABSTRACT: Various factors affect the prognosis of patients with colon cancer. Complicated factors are found to be conducive to accurate assessment of prognosis. In this study, we developed a series of prognostic prediction models for survival time of colon cancer patients after surgery. Analysis of nine clinical characteristics showed that the most important factor was the positive lymph node ratio (LNR). High LNR was the most important clinical factor affecting 1- and 3-year survival; M0&age < 70 was the most important feature for 5 years. The performance of the model was improved through the integration of clinical characteristics and four types of molecule features (mRNA, lncRNA, miRNA, DNA methylation). The model provides guidance for clinical practice. According to the high-risk molecular featu

SUBMITTER: Wang L 

PROVIDER: S-EPMC8176021 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature