Overexpression of LINC00673 Promotes the Proliferation of Cervical Cancer Cells.

ABSTRACT:

Objective

To study the expression of LINC00673 in cervical cancer and cervical intraepithelial neoplasia (CIN) and to explore the role of LINC00673 in the development of cervical cancer.

Methods

The expression of LINC00673 in serum from cervical cancer patients, CIN patients, and healthy participants was detected by RT-qPCR. The function of LINC00673 in cervical cancer cells was analyzed using in vitro and in vivo experiments.

Results

Our results revealed that serum LINC00673 levels were highest in cervical cancer patients, followed by patients with CIN and healthy controls. In vitro experiments demonstrated that overexpression of LINC00673 enhanced the proliferation and cell cycle progression of HeLa and SiHa cells. In vivo experiments sho

SUBMITTER: Huang SK 

PROVIDER: S-EPMC8176101 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature