Macrophage-Hypoxia-Inducible Factor-1α Signaling in Carotid Artery Stenosis.

ABSTRACT: Macrophages play crucial and diverse roles in the pathogenesis of inflammatory vascular diseases. Macrophages are the principal innate immune cells recruited to arterial walls to govern vascular homeostasis by modulating the proliferation of vascular smooth muscle cells, the reorganization of extracellular matrix components, the elimination of dead cells, and the restoration of normal blood flow. However, chronic sterile inflammation within the arterial walls draws inflammatory macrophages into intimal/neointimal regions that may contribute to disease pathogenesis. In this context, the accumulation and aberrant activation of macrophages in the neointimal regions govern the progression of inflammatory arterial wall diseases. Herein, we report that myeloid-hypoxia-inducible factor-1α (HIF1α)

SUBMITTER: Kim GD 

PROVIDER: S-EPMC8176143 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature