Investigating the efficacy and safety of metronidazole during pregnancy; A systematic review and meta-analysis.

ABSTRACT:

Objective

We aimed to review and analyze studies focusing on the efficacy of metronidazole in reducing the risk of preterm birth and the safety of metronidazole taking into account the different doses, duration of treatment and routes of administration.

Study designs

Embase, Cochrane Library and PubMed were searched up to 29 July 2019 to identify studies assessing metronidazole exposure during pregnancy. Additional studies were identified from reference lists of retrieved papers. Measured outcomes were preterm births (<37 weeks of gestation) and associated delivery outcomes such as spontaneous abortions (≤ 20 weeks of gestation), stillbirths (≥20 weeks of gestation) and low birth weight (<2500 g) irrespective of the period of exposure and major malformations after first-trim

SUBMITTER: Ajiji P 

PROVIDER: S-EPMC8176309 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature