Ontology highlight
ABSTRACT:
SUBMITTER: Kuang X
PROVIDER: S-EPMC8176346 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Kuang Xuyuan X Nunn Kyle K Jiang Jennifer J Castellano Paul P Hardikar Uttara U Horgan Arianna A Kong Joyce J Tan Zhiqun Z Dai Wei W
Biochemical and biophysical research communications 20210510
Aggregates of mutant huntingtin (mHTT) containing an expanded polyglutamine (polyQ) tract are hallmarks of Huntington's Disease (HD). Studies have shown that mHTT can spread between cells, leading to the propagation of misfolded protein pathology. However, the structure of transmissive mHTT species, and the molecular mechanisms underlying their transmission remain unknown. Using correlative light and electron microscopy (CLEM) and cryo-electron tomography (cryo-ET), we identified two types of ag ...[more]