Association of the MYOC p.(Gln368Ter) Variant With Glaucoma in a Finnish Population.

ABSTRACT:

Importance

The c.1102C>T, p.(Gln368Ter) variant in the myocilin (MYOC) gene is a known risk allele for glaucoma. It is the most common MYOC risk variant for glaucoma among individuals of European ancestry, and its prevalence is highest in Finland. Furthermore, exfoliation syndrome has high prevalence in Scandinavia, making the Finnish population ideal to study the association of the variant with different types of glaucoma.

Objectives

To examine the association and penetrance of MYOC p.(Gln368Ter) (rs74315329) variant with different types of glaucoma in a Finnish population.

Design, setting, and participants

This genetic association study included individuals of Finnish ancestry in the FinnGen project. The participants were collected from Finnish biobanks, and the dis

SUBMITTER: Liuska PJ 

PROVIDER: S-EPMC8176385 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature