Inhibition of p22^phox Suppresses Epithelial Ovarian Cancer Cell Proliferation and Tumorigenesis.

ABSTRACT: The aim of this study was to investigate the biological role and molecular mechanism of p22^phox in epithelial ovarian cancer. Immunohistochemistry was employed to determine the p22^phox expression level in epithelial ovarian cancer tissues. The effects of p22^phox on epithelial ovarian cancer cell proliferation, tumorigenesis, and chemosensitivity were evaluated by CCK-8, EdU assay, colony formation and apoptosis assays in vitro and by mouse experiments in vivo. Immunoprecipitation analyses were utilized to explore the potential mechanisms of p22^phox mediated downstream signaling, and RT-PCR and western blot were used to confirm the relevance. P22^phox expression could be detected in epithelial ovarian cancer tissues and normal fallopian

SUBMITTER: Li Q 

PROVIDER: S-EPMC8176422 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature