Tumor-derived Exosome Promotes Metastasis via Altering its Phenotype and Inclusions.

ABSTRACT: Although tumor-derived exosomes play an important role in the process of metastasis, differences in exosomes secreted by the same cells at different stages or conditions have not been noticed by most of the relevant researchers. Here we developed a lung cancer model in nude mice, and the phenotype and inclusions of exosomes secreted by early and advanced tumors were analysed. The size distribution and surface topography of these two exosomes were not significantly different, but the expression of CD63 in early tumor exosome (E-exosome) was significantly lower than that in advanced tumor exosome (A-exosome). α-SMA expression on HELF cells treated with A-exosome was significantly higher than that treated with E-exosome. The ability of A-exosome to promote the migration of A549 cells was bett

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC8176431 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature