The association between estrogen receptor 2 gene polymorphism and complexity of coronary artery disease: an analysis in elective percutaneous coronary intervention patients.

ABSTRACT:

Background

One of the most common causes of death in the world is coronary artery disease (CAD). Estrogen, the most important early sex hormones in women, plays an important role in the risk reduction of cardiovascular disease (CVD). Expression of estrogen as well as its receptors including estrogen receptor alpha (ER1) and estrogen receptor beta (ER2) might have an association with the severity or the complexity of CAD. Since most articles have focused on the relationship between ER1 gene polymorphism and CAD, in this study, we aimed to evaluate the association of two ER2 gene polymorphisms, rs4986938 (AluI) and rs1256049 (RsaI), with the severity of CAD.

Methods

148 patients with confirmed CAD who underwent elective percutaneous coronary intervention (PCI) were included in

SUBMITTER: Foroughinia F 

PROVIDER: S-EPMC8176575 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature