Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.

ABSTRACT: Five new [daphneodorins D-H (1, 5, and 10-12)] and seven known daphnane diterpenoids (2-4 and 6-9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1-9) showed potent anti-HIV activity with EC₅₀ values of 1.5-7.7 nM.

SUBMITTER: Otsuki K 

PROVIDER: S-EPMC8176625 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature