Unknown

Dataset Information

0

Association Between Cytomegalovirus and Epstein-Barr Virus Viremia And Human Immunodeficiency Virus DNA Levels in the Reservoir of Kenyan Infants Receiving Antiretroviral Therapy.

ABSTRACT: Identifying determinants of human immunodeficiency virus (HIV) reservoir levels may inform novel viral eradication strategies. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) coinfections were assessed as predictors of HIV proviral DNA level in 26 HIV RNA-suppressed Kenyan children starting antiretroviral therapy before 7 months of age. Earlier acquisition of CMV and EBV and higher cumulative burden of systemic EBV DNA viremia were each associated with higher HIV DNA level in the reservoir after 24 months of antiretroviral therapy, independent of HIV RNA levels over time. These data suggest that delaying or containing CMV and EBV viremia may be novel strategies to limit HIV reservoir formation.

SUBMITTER: Slyker JA 

PROVIDER: S-EPMC8176631 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Association Between Cytomegalovirus and Epstein-Barr Virus Viremia And Human Immunodeficiency Virus DNA Levels in the Reservoir of Kenyan Infants Receiving Antiretroviral Therapy.

Slyker Jennifer A JA   Guthrie Brandon B   Pankau Mark M   Tapia Kenneth K   Wamalwa Dalton D   Benki-Nugent Sarah S   Ngugi Evelyn E   Huang Meei-Li ML   Njuguna Irene I   Langat Agnes A   John-Stewart Grace G   Lehman Dara D  

The Journal of infectious diseases 20210601 11

Identifying determinants of human immunodeficiency virus (HIV) reservoir levels may inform novel viral eradication strategies. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) coinfections were assessed as predictors of HIV proviral DNA level in 26 HIV RNA-suppressed Kenyan children starting antiretroviral therapy before 7 months of age. Earlier acquisition of CMV and EBV and higher cumulative burden of systemic EBV DNA viremia were each associated with higher HIV DNA level in the reservoir af  ...[more]

Similar Datasets

Unknown Cytomegalovirus Viremia and Clinical Outcomes in Kenyan Children Diagnosed With Human Immunodeficiency Virus (HIV) in Hospital.
| S-EPMC8994579 | biostudies-literature
Unknown Cytomegalovirus and Epstein-Barr virus in breast cancer.
| S-EPMC4344231 | biostudies-literature
Clinical Expanded Access Protocol for Tabelecleucel for Patients With Epstein-Barr Virus-Associated Viremia or Malignancies
| 2218995 | ecrin-mdr-crc
Unknown Effect of Malaria Infection on Epstein-Barr Virus Persistence in Kenyan Children.
| S-EPMC10786253 | biostudies-literature
Unknown Epstein-Barr Virus Type 2 Infects T Cells in Healthy Kenyan Children.
| S-EPMC5853903 | biostudies-literature
Unknown Epstein-Barr virus, cytomegalovirus, and multiple sclerosis susceptibility: A multiethnic study.
| S-EPMC5649756 | biostudies-literature
Unknown The effect of Epstein-Barr virus viremia on the progression to severe COVID-19.
| S-EPMC9276369 | biostudies-literature
Unknown Impact of Plasmodium falciparum Coinfection on Longitudinal Epstein-Barr Virus Kinetics in Kenyan Children.
| S-EPMC4760420 | biostudies-literature
Unknown Detection of human cytomegalovirus and epstein-barr virus in coronary atherosclerotic tissue.
| S-EPMC3768663 | biostudies-literature
Unknown Antiretroviral Refill Histories as a Predictor of Future Human Immunodeficiency Virus Viremia.
| S-EPMC8849282 | biostudies-literature