Postoperative troponin increases after noncardiac surgery are associated with raised neurofilament light: a prospective observational cohort study.

ABSTRACT:

Background

Myocardial and neuronal injury occur commonly after noncardiac surgery. We examined whether patients who had perioperative myocardial injury (PMI) also incurred neuronal injury, and whether myocardial and neuronal injury were associated with similar changes in inflammatory markers or overlapping clinical predictors.

Methods

A total of 114 individuals >65 yr old were recruited from two ongoing perioperative cohort studies (NCT02926417; NCT03124303). Plasma samples were collected before and daily after surgery to process assays for troponin I (PMI), neurofilament light (NfL; neuronal injury) and multiplexed plasma cytokines (inflammation). The primary outcome was the change in NfL in individuals with PMI (>40 pg ml^-1 increase in troponin above preoperativ

SUBMITTER: Sanders RD 

PROVIDER: S-EPMC8176651 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature