Cardiac-sparing radiotherapy for locally advanced non-small cell lung cancer.

ABSTRACT:

Background

We have carried out a study to determine the scope for reducing heart doses in photon beam radiotherapy of locally advanced non-small cell lung cancer (LA-NSCLC).

Materials and methods

Baseline VMAT plans were created for 20 LA-NSCLC patients following the IDEAL-CRT isotoxic protocol, and were re-optimized after adding an objective limiting heart mean dose (MD_Heart). Reductions in MD_Heart achievable without breaching limits on target coverage or normal tissue irradiation were determined. The process was repeated for objectives limiting the heart volume receiving ≥ 50 Gy (V_Heart-50-Gy) and left atrial wall volume receiving ≥ 63 Gy (V_LAwall-63-Gy).

Results

Following re-optimization, mean MD_Heart, V_He

SUBMITTER: Turtle L 

PROVIDER: S-EPMC8176693 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature