High frame rate video mosaicking microendoscope to image large regions of intact tissue with subcellular resolution.

ABSTRACT: High-resolution microendoscopy (HRME) is a low-cost strategy to acquire images of intact tissue with subcellular resolution at frame rates ranging from 11 to 18 fps. Current HRME imaging strategies are limited by the small microendoscope field of view (∼0.5 mm²); multiple images must be acquired and reliably registered to assess large regions of clinical interest. Image mosaics have been assembled from co-registered frames of video acquired as a microendoscope is slowly moved across the tissue surface, but the slow frame rate of previous HRME systems made this approach impractical for acquiring quality mosaicked images from large regions of interest. Here, we present a novel video mosaicking microendoscope incorporating a high frame rate CMOS sensor and optical probe holder to e

SUBMITTER: Hunt B 

PROVIDER: S-EPMC8176790 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature