Feasibility of Different Tumor Delineation Approaches for ¹⁸F-PSMA-1007 PET/CT Imaging in Prostate Cancer Patients.

ABSTRACT:

Background

Delineation of PSMA-positive tumor volume on PET using PSMA-ligands is of highest clinical interest as changes of PSMA-PET/CT-derived whole tumor volume (WTV) have shown to correlate with treatment response in metastatic prostate cancer patients. So far, WTV estimation was performed on PET using ⁶⁸Ga-labeled ligands; nonetheless, ¹⁸F-labeled PET ligands are gaining increasing importance due to advantages over ⁶⁸Ga-labeled compounds. However, standardized tumor delineation methods for ¹⁸F-labeled PET ligands have not been established so far. As correlation of PET-based information and morphological extent in osseous and visceral metastases is hampered by morphological delineation, low contrast in liver tissue and movement artefa

SUBMITTER: Mittlmeier LM 

PROVIDER: S-EPMC8176856 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature