ZIKV Disrupts Placental Ultrastructure and Drug Transporter Expression in Mice.

ABSTRACT: Congenital Zika virus (ZIKV) infection can induce fetal brain abnormalities. Here, we investigated whether maternal ZIKV infection affects placental physiology and metabolic transport potential and impacts the fetal outcome, regardless of viral presence in the fetus at term. Low (10³ PFU-ZIKV_PE243; low ZIKV) and high (5x10⁷ PFU-ZIKV_PE243; high ZIKV) virus titers were injected into immunocompetent (ICompetent C57BL/6) and immunocompromised (ICompromised A129) mice at gestational day (GD) 12.5 for tissue collection at GD18.5 (term). High ZIKV elicited fetal death rates of 66% and 100%, whereas low ZIKV induced fetal death rates of 0% and 60% in C57BL/6 and A129 dams, respectively. All surviving fetuses exhibited intrauterine growth restriction (IUG

SUBMITTER: Andrade CBV 

PROVIDER: S-EPMC8176859 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature