Variation in Early Management Practices in Moderate-to-Severe ARDS in the United States: The Severe ARDS: Generating Evidence Study.

ABSTRACT:

Background

Although specific interventions previously demonstrated benefit in patients with ARDS, use of these interventions is inconsistent, and patient mortality remains high. The impact of variability in center management practices on ARDS mortality rates remains unknown.

Research question

What is the impact of treatment variability on mortality in patients with moderate to severe ARDS in the United States?

Study design and methods

We conducted a multicenter, observational cohort study of mechanically ventilated adults with ARDS and Pao₂ to Fio₂ ratio of ≤ 150 with positive end-expiratory pressure of ≥ 5 cm H₂O, who were admitted to 29 US centers between October 1, 2016, and April 30, 2017. The primary outcome was 28-day in-hospital

SUBMITTER: Qadir N 

PROVIDER: S-EPMC8176896 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature